In the UK, developed software that checks the sugars in X-ray crystallographic data from protein structures. Because details of these sugars are too often erroneously into protein databases, set Jon Agirre and colleagues from the University of York.
A press release speaks even of the Cinderellas of biology.
The sugar groups on most human proteins and are essential to their functioning. If you are those proteins is crystallized out with X-ray crystallography, and determines the 3D-structure, the structures of which sugars are automatically entered. But the software afterwards results followeth on details that can theoretically not limited itself so far to the protein chain itself.
Agirre thus estimates that thirty percent of the published protein structures containing sugar chains with five or zesringconformaties (respectively furanoses and pyranoses, in the jargon) that can theoretically any more. And given the rate at which protein structures are currently being cleared up quickly intervene in his necessity.
Nature Structural and Molecular Biology he just presented a software package called Privateer, that protein structures automatically scans on sugars and then see if that is not too much at odds with existing ‘glycobiological’ knowledge. It would thereby be able to pick up on the software that is already being used to validate the protein chain itself
Fans of the source code can download free
source:.. University of York
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